James E. Bradner, MD
Physician and Scientist
Physician-scientist James Bradner, MD, leads a discovery chemistry laboratory at the Dana-Farber Cancer Institute. He and his team are working to discover and develop new chemicals targeting pathways of cellular memory, as powerful tools for basic science and as prototype drugs for cancer medicine.
Dr. Bradner and his team have innovated and exemplified a new model of drug discovery, which empowers the international research community with free and unrestricted access to first-in-class drugs. In a field often driven by competitiveness and lengthy, secretive processes, Dr. Bradner is a vigorous advocate of open-source drug discovery, which promises to expedite the rapid translation of new medicines.
When Dr. Bradner’s laboratory discovered a molecule that, in mice, tricks certain cancer cells into behaving as normal cells, he sent samples to labs around the world. The strategy, he told The Atlantic, offers a “more efficient way to do science — and maybe the more honorable way.”
An associate member of the Chemical Biology Program at the Broad Institute and an assistant professor at Harvard Medical School, Dr. Bradner is also a scientific advisor to TargetCancer, which supports fast-track development of therapies for rare cancers. He facilitated its grant-making partnership with Nabeel Bardeesy, PhD, at Mass General, who is building the first comprehensive research program for cholangiocarcinoma.
Help us honor the 2014 one hundredNominate Your Cancer Hero
- Jennifer E. D’Alotto, MSW, LCSW
- Harrison Strickler
- Kathleen A. Stakes, RN, MS, CPON
- Jeff Warren
- Big Y
- Sue de Vries Cancer Foundation
- Estelle Sugarman
- Jeanne Griffin Vaughn, NP
- Tristan’s Gift of Hope Foundation
- Lori Wirth
- Yi-Bin A. Chen, MD
- Bruce A. Chabner, MD
- Philip Gosnell
- David J. Kuter, MD, Dphil
- Robert Howe
- Melissa Skolny, MSHA, Cynthia Miller; Lauren Jammallo; Jean O’Toole, PT, MPH; and Michelle Specht, MD, Mass General Lymphedema Screening Team
- Shiv Pillai, MD, PhD
- Lazarex Foundation
- Breast Intentions, Massachusetts Chapter
- Kevin Campbell
- Jason Maxwell
- James E. Bradner, MD
- Friends of Jaclyn
- Marla Serwin
- Anne Fallon
- Evangelos S. Gragoudas, MD
- Pamela Manikas Washek
- Farrah Fawcett and the Farrah Fawcett Foundation
- St. Mary’s High School Baseball Team
- Lori Grassette
Mass General honors 100 individuals and groups for their diverse contributions to the fight against cancer.
There is strength in numbers and Massachusetts General Hospital Cancer Center proves this each year. the one hundred is the Cancer Center’s annual fundraiser, honoring 100 individuals and groups whose diligence and discoveries, philanthropy and passion have helped advance the fight against cancer. Funds raised at the gala support research, patient care, education and community outreach programs. Meet the Honorees.