In his more than 30 years of cancer research, Harold Moses, MD, has revolutionized our understanding of tumor growth and suppression by unlocking the mysteries of cancer at the molecular level.
Dr. Moses is the Ingram Professor of Cancer Research, the director of the Frances Williams Preston Laboratories, professor of Cancer Biology, Medicine and Pathology at Vanderbilt University School of Medicine, and director emeritus of the Vanderbilt-Ingram Cancer Center in Nashville, Tenn. He is an elected member of the Institute of Medicine of the National Academies and was the founding chair of its National Cancer Policy Forum.
His laboratory’s seminal discovery of transforming growth factor-beta (TGF-beta) paved the way for deciphering the intricate signaling networks that regulate normal and abnormal cell growth. In the 1980s, his group demonstrated that TGF-beta molecules could suppress the formation of breast tumors in animal models and that the loss or inactivation of TGF-beta signaling could create an environment conducive to tumor growth. These types of inactivating mutations occur with high frequency in many types of human cancer.
Other work from Dr. Moses and his team has revealed that in some situations TGF-beta molecules can function as tumor promotors instead of tumor suppressors. Unraveling the complex behavior of the TGF-beta family of molecules is vital to solving the cancer challenge.
In 2013, Dr. Moses was honored with the Annual Award for Lifetime Achievement in Cancer Research by the American Association for Cancer Research for his pioneering contributions to the field and his extraordinary leadership. Dr. Moses’ research is maximizing opportunities for cancer prevention and cure.
Dr. Harold Moses unlocks the mysteries of cancer at the molecular level. Story told by Jordan Rich of The Jordan Rich Show on WBZ NewsRadio 1030. Visit www.theonehundred.org to learn more and meet the rest of our honorees.